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Now Available for Public Comment: ORD Staff Handbook for Developing IRIS Assessments

This original announcement was published by EPA’s Health and Environment Risk Assessment team on November 10, 2020. Click here for more information. 


Notice: EPA’s Integrated Risk Information System (IRIS) Program released the Office of Research and Development (ORD) Staff Handbook for Developing IRIS Assessments, or IRIS Handbook, for a 90-day public comment period. The IRIS Handbook provides operating procedures for developing IRIS assessments including problem formulation approaches and methods for conducting systematic review, dose response analysis, and developing toxicity values.

EPA is submitting a notice for publication in the Federal Register (FR). Please refer to the official notice in a forthcoming FR publication, which will appear on the Federal Register website ( and on ( in Docket No. EPA-HQ-ORD-2018-0654. Once published in the Federal Register, an additional IRIS listserv notice will be distributed to notify the public.

For more information on this document, please visit the EPA IRIS website.