Now Available: Registration for upcoming IRIS Public Science Meeting (November 2021)

This original announcement was published by the EPA on September 30, 2021. Click here to register.


The U.S. Environmental Protection Agency’s (EPA) Health and Environmental Risk Assessment (HERA) National Research Program is announcing a virtual IRIS Public Science Meeting for November 9, 2021. The Integrated Risk Information System (IRIS) Program is convening the previously postponed IRIS Public Science Meeting to discuss the IRIS Assessment Plan associated with the unsuspended naphthalene assessment.

Should you wish to attend the meeting and/or provide oral public comment, register here. Program materials, including the assessment plan, can be found on the Public Science Meeting website. Interested stakeholders may view the public comment received on the naphthalene IAP by visiting Regulations.Gov (Docket no. EPA-HQ-ORD-2014-0527). While IRIS assessments are not associated with proposed rulemaking, serves as both an internal portal to facilitate public comment and as a document repository for Federal government agencies.

Call for Nominations — Review of EPA’s 2021 Draft IRIS Formaldehyde Assessment

EPA’s HERA National Research Program is highlighting that an ad hoc committee of the National Academies of Sciences, Engineering, and Medicine (NAS) will provide the Environmental Protection Agency (EPA) with a review of EPA’s 2021 draft IRIS formaldehyde assessment. An ad hoc committee will assess whether the draft assessment adequately and transparently evaluated the scientific literature, used appropriate methods to synthesize the current state-of-the science, and presented conclusions regarding the hazard identification analysis and dose-response analysis of formaldehyde that are supported by the scientific evidence. The committee will not conduct its own hazard assessment of formaldehyde, nor will the committee address broader aspects of the IRIS Program.

Nominations for committee members and/or reviewers for this study are due by October 15, 2021. For more information regarding this peer review, visit the NAS website.

Now Available: Draft Supplement to the 2019 Integrated Science Assessment for Particulate Matter (PM ISA Supplement)

This original announcement was published by the EPA on September 30, 2021. Click here for more information!


Notice:  EPA’s Health and Environmental Risk Assessment (HERA) National Research Program is announcing for public comment and external peer review the release of the draft Supplement to the 2019 Integrated Science Assessment for Particulate Matter (PM). The HERA research program has been designed to develop and apply state-of-the-science research to characterize impacts on human and ecological systems – whether they result from exposure to single, complex, or multiple physical, chemical, or biological stressors – to support and improve EPA’s risk assessment and risk management decisions. Integrated Science Assessments (ISAs) fall under HERA’s Science Assessment Development Research Area which is focused on producing high quality, transparent, consistent, and scientifically-defensible assessment products to meet EPA’s diverse statutory and policy needs.

This draft Supplement represents a targeted evaluation of recent studies published since the literature cutoff date for the 2019 PM ISA. The 2019 PM ISA and this Supplement form the complete scientific record for the ongoing reconsideration of the primary (health-based) and secondary (welfare-based) National Ambient Air Quality Standards (NAAQS) for PM. The 2019 PM ISA and Supplement, in conjunction with additional technical and policy assessments, will inform EPA’s decisions on the reconsideration of the current NAAQS and the appropriateness of possible alternative standards.

The draft assessment is available for a 60-day public comment period, which ends on November 29, 2021. Written comments should be submitted to EPA-HQ-ORD-2014-0859 via Comments submitted to EPA, via the public docket, will be provided to the external peer review panel. The date and location of a public meeting for the external peer review panel will be specified in a separate Federal Register notice.

For more information on the PM ISA Supplement, including how to submit comments, please visit the Federal Register or the EPA ISA website. For more information on HERA, please see the program’s Strategic Research Action Plan.

Now Available for Public Comment: ORD Staff Handbook for Developing IRIS Assessments

This original announcement was published by EPA’s Health and Environment Risk Assessment team on November 10, 2020. Click here for more information. 


Notice: EPA’s Integrated Risk Information System (IRIS) Program released the Office of Research and Development (ORD) Staff Handbook for Developing IRIS Assessments, or IRIS Handbook, for a 90-day public comment period. The IRIS Handbook provides operating procedures for developing IRIS assessments including problem formulation approaches and methods for conducting systematic review, dose response analysis, and developing toxicity values.

EPA is submitting a notice for publication in the Federal Register (FR). Please refer to the official notice in a forthcoming FR publication, which will appear on the Federal Register website ( and on ( in Docket No. EPA-HQ-ORD-2018-0654. Once published in the Federal Register, an additional IRIS listserv notice will be distributed to notify the public.

For more information on this document, please visit the EPA IRIS website.